mPEG-PLLA Microspheres

mPEG-PLLA (methoxy polyethylene glycol-poly-L-lactic acid) microspheres, as a new generation of medical regenerative materials, are an upgraded product developed based on poly-L-lactic acid (PLLA) microspheres. Their biocompatibility, biodegradability, and biosafety have all been significantly improved. By integrating the core advantages of polyethylene glycol (mPEG) and poly-L-lactic acid (PLLA), an amphiphilic polymer microsphere with superior performance is formed. The introduction of mPEG segments greatly enhances the hydrophilicity of the microspheres, effectively improving their dispersibility in bodily fluids and tissue compatibility, thereby reducing the risk of adverse reactions such as aggregation and nodule formation after injection. After entering the human body, mPEG-PLLA microspheres can be completely degraded and absorbed. The intermediate degradation product, lactic acid, is a normal metabolite in the human body, with no biological activity and minimal irritation, and is ultimately metabolized into carbon dioxide and water for excretion. With no risk of accumulation, it fundamentally avoids secondary injury, making it a highly favored regenerative material in the biomedical field.