PLGA Microspheres

PLGA (poly(lactic-co-glycolic acid)) microspheres are customizable biomedical polymer microsphere materials with excellent biocompatibility and biodegradability. Their degradation rate can be precisely controlled by adjusting the copolymerization ratio of lactic acid (LA) and glycolic acid (GA), making them suitable for both long-acting and short-acting applications.

Among these, the 50:50 and 75:25 ratios are the two most widely used specifications in clinical applications. Their key differences lie in degradation behavior and application suitability. PLGA microspheres with a 50:50 ratio, due to the balanced LA/GA composition, exhibit faster degradation and higher hydrophilicity, making them suitable for short-term drug release and superficial aesthetic filling for fine lines. PLGA microspheres with a 75:25 ratio have a higher LA content, resulting in increased hydrophobicity, a longer degradation period, and superior mechanical strength. These characteristics make them suitable for long-term drug delivery, tissue engineering scaffolds, and other applications requiring greater stability.

Both specifications ultimately degrade into carbon dioxide and water, leaving no residual accumulation.